Instructions for use Title A Novel Metabolic Pathway for Glucose Production Mediated by α - Glucosidase - catalyzed

نویسندگان

  • Young-Min Kim
  • Wataru Saburi
  • Shukun Yu
  • Hiroyuki Nakai
  • Janjira Maneesan
  • Min-Sun Kang
  • Seiya Chiba
  • Doman Kim
  • Masayuki Okuyama
  • Haruhide Mori
  • Atsuo Kimura
چکیده

Right This research was originally published in Journal of Biological Chemistry. Young-Min Kim; Wataru Saburi; Shukun Yu; Hiroyuki Nakai; Janjira Maneesan; Min-Sun Kang; Seiya Chiba; Doman Kim; Masayuki Okuyama; Haruhide Mori; Atsuo Kimura. A Novel Metabolic Pathway for Glucose Production Mediated by α-Glucosidase-catalyzed Conversion of 1,5-Anhydrofructose. Journal of Biological Chemistry. 2012; 287:22441-22444. © the American Society for Biochemistry and Molecular Biology. Type article (author version)

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A novel metabolic pathway for glucose production mediated by α-glucosidase-catalyzed conversion of 1,5-anhydrofructose.

α-Glucosidase is in the glycoside hydrolase family 13 (13AG) and 31 (31AG). Only 31AGs can hydrate the D-glucal double bond to form α-2-deoxyglucose. Because 1,5-anhydrofructose (AF), having a 2-OH group, mimics the oxocarbenium ion transition state, AF may be a substrate for α-glucosidases. α-Glucosidase-catalyzed hydration produced α-glucose from AF, which plateaued with time. Combined reacti...

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تاریخ انتشار 2017